Recently, there’s been an increasing interest in the potential of magic mushrooms in managing various mental health issues, particularly depression. A popular method involves the regular intake of around 25 mg of the active ingredient, available for purchase at a mushroom dispensary. This dosage is showing promise for providing relief and could complement conventional depression treatments.
A study conducted by a group of scholars indicates that psilocybin, the active component in magic mushrooms, has demonstrated promising results in the treatment of depression.
Key Points:
- Psilocybin can result in an improvement in depression symptoms in as few as eight days.
- The side effects of psilocybin are typically manageable and often mild to moderate.
- A 25mg dosage of psilocybin can cause changes in perception, mood shifts, increased creativity, and a feeling of unity.
Just One Dose Could Do the Trick
A recent research uses a rigorous methodology involving a randomized, multi-blinded design to compare a single dose of psilocybin with an active placebo (niacin). The study evaluated the onset, benefits duration, and safety of psilocybin over six weeks.
The Study Participants
The study targeted individuals aged 21 to 65 who met the Major Depressive Disorder (MDD) criteria as defined in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) and were in the midst of a depressive episode lasting at least 60 days.
The Procedure
Participants received either a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. Niacin served as an active placebo, causing an immediate physical response (flushing) to maintain the blinding integrity.
Both the psilocybin and the niacin placebo were given following a standard “set and setting” procedure. The preparation sessions were led by two facilitators and lasted between 6 and
Participants were administered their doses in a relaxed environment over a period of 7 to 10 hours. Four hours after taking the dose, they were invited to introspect about their experiences.
Findings of the Study
Just eight days after psilocybin was administered, participants exhibited noticeable signs of depression alleviation. This positive impact continued to be observed throughout the six-week check-in period. When assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), the response and remission rates were higher compared to other psilocybin studies concerning Treatment-Resistant Depression.
Psilocybin outperformed niacin in terms of improving psychosocial functioning. The use of psilocybin showed promise in various aspects, including reducing the overall severity of the disease, diminishing anxiety, lessening self-reported depressive symptoms, and improving life quality.
The majority of participants tolerated psilocybin well, with only minor to moderate side effects primarily occurring after the first dose. However, compared to niacin, psilocybin was associated with more frequent and severe side effects, which is consistent with our current understanding of its effects.
The researchers highlighted that psychedelics like psilocybin could produce side effects that may not always be captured by standard rating scales or could reveal previously unidentified psychiatric conditions, even as they effectively manage certain disorders.
Implications of a 25-mg Dose
The typical psychedelic dose varies between 15 to 25 milligrams of psilocybin (equivalent to 1.5 to 2.5 grams of dried mushrooms), which is the standard dosage for those seeking the full psychedelic effects of magic mushrooms.
This dose can induce changes in perception, mood alterations, amplified creativity, and a feeling of unity with the surroundings. Mild visual effects are common, but intense hallucinations are rare. The experience is akin to entering a vivid dream world where reality and a captivating mix of visual and auditory sensations blend effortlessly.
The euphoric sensations often express themselves through dance, subtle movements, or simply surrendering to the psychedelic rhythm. The experience usually lasts from 4 to 8 hours. At this level, visual distortions may become more evident. Patterns seem to come alive and morph, and the surroundings seem to pulsate with energy.
While this dose can be controlled, it necessitates a secure setting and a positive mindset. It offers a journey filled with amazement and discovery, encouraging exploration of consciousness. with thoughtful excitement.
- An enhanced perception of colours.
- Visual distortions, such as fluctuating or “breathing” objects.
- Experiencing synesthesia, like “seeing sounds” or “hearing colours”.
- Developing a deep appreciation for music.
- Occasional bursts of laughter.
- Alterations in touch sensations.
- Engagement in self-reflection.
- Feelings of euphoria.
- Distortions in time perception.
- An elevated heart rate and blood pressure.
Products You Can Find at Magic Mushroom Stores
Magic mushroom shops offer a plethora of psilocybin-infused products. These stores supply a variety of options including dried mushrooms, edibles, capsules, drinks, and more. Dried mushrooms are particularly favored.
Health Canada recognizes over 200 types of magic mushrooms, with Psilocybe cubensis being a commonly sold type. This strain is available in several forms, providing customers with a broad selection, similar to the choices at cannabis dispensaries.
Other Shroom Products Include:
| Edibles | Food products like gummies and chocolates infused with psilocybin. The dosage is simplified since the manufacturers specify the amount per serving. |
| Capsules | These are tasteless and can be easily included in your wellness routine. They contain only small quantities to ensure a gentle enhancement to your regimen. |
| Beverages | Comparable to edibles, but in a drinkable form. They come in a variety of forms, such as chocolate, coffee, or tea. |
How to Determine Your Dose at Magic Mushroom Dispensaries
Although magic mushrooms aren’t widely recognized as a depression treatment, Canada has taken a progressive step. They have approved the testing and medical use of psilocybin, a Schedule I substance under the Controlled Drugs and Substances Act, for certain patients dealing with severe major depressive disorder. This move could potentially help tens of thousands
Exploring alternative treatment options through clinical trials may be beneficial for those battling anxiety and depression.
Commonly Asked Questions
Can you buy psilocybin from a medicinal mushroom dispensary?
A medicinal mushroom dispensary typically carries products like Reishi, Turkey Tail, and Lion’s Mane. If you’re interested in delving into the realm of mushrooms, an online magic mushroom dispensary might be your best bet. These dispensaries offer a wide range of mushroom products, including dried mushrooms and other psychedelic substances.
Is a 25 mg dose effective for depression treatment?
Research into the appropriate psilocybin dosages for treating depression is still ongoing. Some studies have looked into lower dosages, while others have explored the effects of higher psilocybin quantities. A possible approach could include starting with a microdose and gradually increasing the dosage.
Can you buy shrooms in Toronto?
Online mushroom sellers have made it possible to shop from any location in Canada. Regardless of your province or city, these online platforms ensure delivery right to your doorstep.
What is the most budget-friendly product in an online mushroom shop?
Dried mushrooms are often the preferred choice for customers because of the variety of quantities available. The price can vary depending on whether you need a small amount like 1 gram or wish to purchase in bulk. While edibles and other products are reasonably priced, they may not be as cost-efficient as dried mushrooms.
Can a single dose of shrooms help alleviate depression?
Some studies suggest that a one-time usage could potentially lessen depression symptoms. However, it’s important to remember that the subjects of these studies also participated in talk therapy along with the treatment. The combination of psychedelic therapy and therapeutic sessions appears to yield the best results.
About the Author
This article was penned by Charles L. Raison et al.; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito.
In addition to Richard J. Stevenson, the article also recognizes the contributions of Rebecca Smausz, Joanna Neill, and John Gigg.
Affiliated Institutions:
- Usona Institute, located in Fitchburg, Wisconsin
- SUNY Downstate Medical Center in Brooklyn, New York
- Neurogenesis Clinics, also in Brooklyn, New York
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Center for Psychedelic and Consciousness Research, affiliated with Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Department of Neuroscience, part of Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Again, the Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine, Baltimore, USA
- Department of Cognitive Science, Macquarie University, Sydney, Australia
- Department of Psychology, Macquarie University, Sydney, Australia
- The Division of Neuroscience and Experimental Psychology, part of the Faculty of Biology, Medicine and Health at The University of Manchester, Manchester, UK
- Division of Pharmacy and Optometry, part of the Faculty of Biology, Medicine and Health at The University of Manchester, Manchester, UK
- Medical Psychedelics Working Group, connected to Drug Science, UK
