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Alzheimer’s Disease (AD) is a crippling neurodegenerative condition that currently has no known cure. With its increasing prevalence, it presents a substantial challenge. Researchers are investigating better treatment strategies by exploring both natural and synthetic alternatives. 

Many clinical trials have highlighted the promising potential of serotonergic psychedelics such as LSD, DMT, and psilocybin, for the treatment of Alzheimer’s disease. For more fascinating information, please feel free to explore online resources or consider “purchasing psychedelics online in Canada.”

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The Function of Psychedelics in Alzheimer’s Treatment

Traditional psychedelics demonstrate promise in the treatment of initial-stage Alzheimer’s Disease (AD) or mild cognitive impairment (MCI) by facilitating the growth of brain cells.

Psychedelics may stimulate neural plasticity for learning and memory by targeting specific brain receptors. This could potentially slow down or even reverse the neurodegenerative effects of AD. Furthermore, psychedelics could relieve depression and anxiety, frequently seen in AD patients, by generating positive psychological impacts.

Questions remain about how psychedelic treatments work. Some suggest that profound effects from high-dose psychedelics, such as mystical sensations or a sense of self-dissolution, are essential for gaining psychological benefits. Others believe that the biological changes induced by these substances are the key. Both viewpoints may have merit.

Traditional psychedelics appear to aid the brain in adapting and reducing inflammation, even at lower doses. Thus, low-dose treatments could benefit conditions like brain degeneration or migraines without significant mind-altering effects. However, for depression, anxiety, or addiction, the mind-altering effects seem vital, leading to introspection and behavioural modifications. Hence, both low and high doses should be considered for personalized therapy.

The Impact of Serotonergic Psychedelics

Serotonergic psychedelics, including LSD (lysergic acid diethylamide), DMT (dimethyltryptamine), and psilocybin (found in magic mushrooms), are garnering

Psychedelics are gaining increased attention for their potential therapeutic effects on a range of mental health disorders.

Experts believe that serotonin receptors, recognized for their role in improving cognition and modulating neuroplasticity, pose an exciting focus for Alzheimer’s Disease (AD) research.

Psychedelics chiefly exert their pharmacological actions by modifying the brain’s serotonin system. This results in alterations in perception, mood, and consciousness. The conclusions from diverse studies that endorse this theory include:

  • In particular, the 5-HT2A subtype of the receptors impacts the gene expression of neuroplasticity-boosting neurotrophins in brain areas affected by AD.
  • These receptors supervise cortical signalling, vital for cognition, memory, and synaptic plasticity.
  • Despite their atypical distribution within neurons, serotonin receptors contribute to neural growth, renewal, and plasticity.

Significant Research Findings

  • Serotonergic psychedelics have shown potential in alleviating aspects of AD pathology by promoting neuroplasticity.
  • Classic psychedelics influence neurotransmission, promote synaptic remodeling, and augment factors aiding neuronal survival.
  • Specific psychedelics like muscimol and Sig-1R agonists might reduce the neurotoxicity associated with AD progression.
  • Classic psychedelics activate pathways in brain areas affected by AD, suggesting potential for slowing down or reversing brain degeneration.
  • Psilocybin mushrooms initiate neural plasticity to stimulate neurogenesis and bring about lasting changes in brain circuits.
  • Psychedelics enhance brain connectivity by targeting receptor genes and triggering alterations in neurons and networks.

Clinical research suggests that both classic and non-classic psychedelics from magic mushrooms impact various biological mechanisms in the brain. These impacts encompass immediate changes in gene expression and substantial modifications in brain structure and functionality.

These psychedelics engage with receptors such as serotonin, sigma, NMDA, and GABA, resulting in improved synaptic plasticity and brain revitalization. Consequently, psychedelics could potentially exert positive effects on behaviour, memory, and cognition, positioning them as promising potential treatments for AD and related conditions.

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  1. LSD

LSD, a man-made drug, is derived from a fungus called ergot, commonly found on rye grains. This potent psychoactive compound has the power to modify perceptions, emotions, and cognitions even in low quantities.

Excessive consumption of LSD can lead to severe hallucinations, warping your comprehension of time and space. Proceed with caution, as substances marketed as LSD could potentially be other drugs such as NBOMe or a member of the 2C drug family.

ProductKittease – Ketamine Microdose Troche (30x50mg)Zenly – LSD Gel Tabs – 600ug (100ug Per Tab)Zenly – LSD Gummies – Sour Zen Berry – 200ug (100ug Per Gummy)
Purposed UseStress, depression, pain management, PTSD, OCD, occupational stress, performance anxiety, insomnia, and addiction.Remarkable experiencesRemarkable experiences
Dosage50mg per troche / 30 per pack – 1.5 grams of ketamine/ per pack600ug total/6 Tabs (100ug/Tab)200ug total/2 Gummies (100ug/Gummy)
Recommended UsageConsume one full trocheIngest one full tab to feel the full effect. Allow at least 2 hours before taking another.Consume one full gummy to feel the full effect. Allow at least 2 hours before taking another.
AdvantagesRapid action with minimal risk, increased openness, ideal for introspection and cognitive enhancement.Accurately measured dose for the perfect journey, lab-testedAccurately measured dose for the perfect journey, lab-tested
  1. Magic Mushrooms

Over 180 species of mushrooms have been found to contain psilocybin and psilocin, compounds acknowledged for their therapeutic advantages and positive impact. on mental well-being. 

The impact can vary based on the type of mushroom, the specific cultivation batch, the amount consumed, and the individual’s tolerance level. Some people prefer to microdose for gentle effects, while others consume larger amounts for a deeper experience. The quality can also differ based on the cultivation techniques used.

The Blue Meanies, scientifically known as Panaeolus cyanescens, are small dried mushrooms that flourish in warm tropical climates, typically on cow and water buffalo dung. As they grow, they display blue spots on their surface, which is how they got their name.

  • These mushrooms are rich in psilocybin and psilocin, which are highly concentrated. 
  • They have a history of recreational use, especially among the Balinese people, who consume them during celebrations and for artistic inspiration.
  • They are popular among tourists and travelers in Bali and similar places due to their psychedelic properties. These effects can include feelings of euphoria, hallucinations, happiness, and intense laughter.
  1. DMT

DMT, a potent psychedelic compound, is found in certain plants such as Psychotria viridis and Chacruna. Often called the “spirit molecule,” these controlled substances can trigger deep psychedelic experiences. They offer a short, yet intensely immersive journey characterized by vivid visual and auditory hallucinations. 

ProductDream Machine – Vape Cartridge – DMT 1mlIntegral Alchemist – ACACIA Changa Pre-RollIntegral Alchemist – Mimosa- 1ml DMT Vape Cart
DescriptionExplore hyperdimensional realms with DMT.Experience ayahuasca-like effects by combining a mix of herbs and DMT.Set off on a journey of mystical visions and spiritual insights with DMT.
DMT Content1gAbout 90mg1ml
InstructionsPreheat the cartridge and inhale Proceed to smoke the pre-roll at a pace that suits your comfort.Take in the vapor for instant effects.
EffectsIntense hallucinations, altered consciousness state.Long-lasting visual psychedelic experience.Spiritual awakening, intense joy, significant changes in perception.
DurationVaries from person to personCan last up to 1 hourMay last up to 30 minutes

Long-Term Implications of Psychedelic Use

Current research is focused on understanding the enduring effects of consuming psychoactive substances. Although this area of study is still expanding, “long-term effects” refer to any lasting changes in cognition, emotions, or memory as a result of prolonged psychedelic use.

The study of the long-term effects of psychedelics is complex. Some studies suggest potential mental health benefits, whereas others indicate possible risks, such as the onset of psychosis.

Despite these complexities, researchers persist in their efforts to understand the long-term effects of psychedelic use on mental health. They undertake thorough research, tracking individuals over long periods to collect more accurate data.

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Research suggests a significant shift in Alzheimer’s disease treatment, indicating that psychedelics could bring about a revolution in how we approach neurological disorders. Experts propose that the therapeutic use of such substances could completely alter Alzheimer’s treatment, offering renewed optimism for numerous patients and their families.

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Frequently Asked Questions

What distinguishes psychedelics from other substances commonly used in Alzheimer’s treatments?

Psychedelics differentiate themselves from traditional Alzheimer’s medications through their therapeutic approach and effects. They promote the formation of new neural connections by targeting the brain’s serotonin system, leading to profound psychological experiences that enhance emotional health.

Unlike conventional drugs that primarily manage symptoms, psychedelics are being assessed by Health Canada for their long-lasting benefits and holistic treatment approach, which includes therapy.

Research into the use

The potential of psilocybin in treating conditions such as obsessive-compulsive disorder, coupled with its safety record in preventing multi-organ system failure, distinguishes it from other traditional controlled substances.

Is the use of psychedelics in therapy a viable treatment alternative for Alzheimer’s patients facing end-of-life distress?

Psychedelic-assisted therapy could offer possible benefits to Alzheimer’s patients who are critically ill and confronting the imminence of their mortality.

  • It offers emotional comfort. This therapy method has been observed to lessen feelings of anxiety and depression in some people, especially those who are critically ill. This could potentially extend to Alzheimer’s patients as well.
  • Generally safe when supervised. When given in a controlled setting under the direction of a professional therapist, the use of psychedelics usually poses no harm and is generally well received by most individuals.
  • Could improve quality of life. The emotional uplift provided by this therapy could make a significant difference to an Alzheimer’s patient, irrespective of any lack of improvement in memory problems.
  • Further research is required. Despite the promise this therapy shows, more studies are needed to validate its safety and effectiveness for Alzheimer’s patients, especially those at the end of their lives.

How long does a psychedelic therapy session for Alzheimer’s patients last?

  1. Preparation Stage. This stage involves one or two sessions, each running from 1 to 2 hours. The purpose of these sessions is to ready the patient for the impending experience, manage expectations, and establish trust with the therapist.
  2. Core Psychedelic Session. This key session, during which the patient consumes the psychedelic substance, typically lasts between 4 to 6 hours. The patient spends this period in a controlled environment, typically reclining with eye covers and listening to music, while therapists monitor closely.
  3. Integration Stage. After the session, follow-up meetings are held to help the patient interpret and integrate their experience. These sessions usually run for 1 to 2 hours each, with the number of sessions varying based on individual needs.

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